Symbol
Name
ID

Wt1
WT1 transcription factor
MGI:98968

Phenotype annotations related to renal/urinary system

*	Aspects of the system are reported to show a normal phenotype.
!	Indicates phenotype varies with strain background.
	Darker colors indicate more annotations

Human Phenotypes	Proteinuria	Diffuse mesangial sclerosis	Focal segmental glomerulosclerosis	Enlarged kidney	Nephropathy	Nephrotic syndrome	Renal insufficiency	Stage 5 chronic kidney disease	Nephroblastoma
Disease(s) Associated with WT1	Proteinuria	Diffuse mesangial sclerosis	Focal segmental glomerulosclerosis	Enlarged kidney	Nephropathy	Nephrotic syndrome	Renal insufficiency	Stage 5 chronic kidney disease	Nephroblastoma
Denys-Drash syndrome
Frasier syndrome
nephroblastoma
nephrotic syndrome type 4

Mouse Phenotypes

renal/urinary system phenotype

abnormal kidney interlobular artery morphology

abnormal glomerular capillary morphology

abnormal kidney vasculature morphology

abnormal mesangial cell morphology

increased mesangial cell number

increased metanephric mesenchyme apoptosis

kidney cyst

kidney cortex cyst

increased urine protein level

albuminuria

glomerulonephritis

juxtaglomerular cell hyperplasia

abnormal glomerular capsule parietal layer morphology

decreased glomerular capsule space

abnormal podocyte morphology

absent podocyte foot process

podocyte foot process effacement

podocyte hypertrophy

podocyte microvillus transformation

increased renal glomerulus basement membrane thickness

abnormal renal glomerulus morphology

expanded mesangial matrix

mesangiolysis

glomerulosclerosis

glomerular crescent

abnormal kidney development

absent metanephros

renal interstitial fibrosis

small kidney

dilated renal tubule

renal cast

kidney failure

Availability

Mouse Genotype

Wt1^tm1Asc/Wt1^tm1Asc

Wt1^tm1Jae/Wt1^tm1Jae

Wt1^tm1Mlh/Wt1^tm1Mlh

Wt1^tm2Asc/Wt1^tm2Asc

Wt1^tm1.1Lahe/Wt1⁺

Wt1^tm1Asc/Wt1⁺

Wt1^tm1Mlh/Wt1⁺

Wt1^tm1Vih/Wt1⁺

Wt1^tm2Hst/Wt1⁺

Wt1^tm1.1Ceng/Wt1^tm1.1Ceng
Tg(tetO-cre)LC1Bjd/0
Tg(NPHS2-rtTA2*M2)1Jbk/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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